Vaccine administration encompasses the process of delivering vaccines to trigger immunity against infectious diseases. Various methods are employed, such as injections (intramuscular, subcutaneous, intradermal), oral administration, nasal sprays, and microneedle patches. The objective of delivery systems is to effectively stimulate the immune system, while also ensuring vaccine stability and minimizing adverse reactions. Advanced techniques are being explored to discover novel delivery routes that can enhance immunogenicity and improve accessibility.